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Tadalafil is metabolized predominantly by the hepatic CYP3A4 enzyme system.

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Tadalafil, sildenafil, and vardenafil all act by inhibiting the PDE5 enzyme.

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Help About Wikipedia Community portal Recent changes Contact page.Soon, in 1994, ICOS received a patent for compound IC351 (structurally unlike sildenafil and vardenafil), and Phase 1 clinical trials began in 1995.On November 21, 2003 the FDA approved tadalafil (as Cialis) for sale in the United States as the third ED prescription drug pill (after sildenafil (Viagra) and vardenafil (Levitra)).How to get viagra professional in uk viagra. and. Buy citalopram 40 mg pills cheap online free viagra.

In May 2002, Lilly ICOS reported to the American Urological Association that clinical trial testing demonstrated that tadalafil was effective for up to 36 hours, and one year later, the FDA approved tadalafil.

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The most common side effects when using tadalafil are headache, stomach discomfort or pain, indigestion, burping, acid reflux, back pain, muscle aches, flushing, and stuffy or runny nose.

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This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cyclic guanosine monophosphate (more commonly known as cyclic GMP or cGMP) in smooth muscle cells. cGMP relaxes smooth muscle and increases blood flow to the corpus cavernosum.

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Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose.

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